Research Opportunity: A clinical trial investigating the effects of morphine on IPF cough.

Logo of Royal Brompton and Guys and St Thomas Hospitals
October 2021

Are you interested in using your lived experience and voice to help us shape the future pulmonary fibrosis research?

This study is now closed for recruitment and this information is for reference only.

The PAciFY Study is one of several clinical trials currently recruiting participants in the UK.  You can search for all available trials using the European Pulmonary Fibrosis Federation (EU-IPFF) clinical trial finder or by searching on  

If you are interested in taking part in a clinical trial, you must speak to your clinical team.    

What is the PAciFY Study?  

The PAciFY Study is a Phase 3 clinical trial.  The study is investigating the effect that a low dose of morphine may have on cough count and the quality of life of patients with IPF.  All patients will receive morphine and a placebo (a tablet with no active ingredients) at different times during the study.    

Can I take part?

You may be able to take part if you have received a diagnosis of IPF in the last 5 years and have had a cough for more than 8 weeks.

In all clinical trials, there are lots of different reasons why you may or may not be able to take part.  These are known as inclusion and exclusion criteria. Only the clinical trial team will be able to fully determine whether you are able to take part in the study.

What is involved?

• This study involves taking morphine in tablet form and a placebo tablet at different times during the trial.

• You would need to visit the hospital 3 times, and also be contacted via telephone or video communication twice over the course of 7 weeks.  

• You would have medical assessments, including blood tests, and be asked to wear a cough monitor and Fitbit device 4 times during the study, each for a period of 24 hours.  There are surveys to complete, which will be sent to you via email.  

Where in the UK is this study taking place?

This study is currently recruiting participants at the Royal Brompton Hospital, London and Aintree University Hospital, Liverpool.  

Patients who are willing to travel to take part in the study may also be eligible to participate.    

More information about this study can be found at or by emailing

You must discuss all aspects of your participation or interest in participating in a clinical trial with your medical team.

This post provides information about an opportunity to participate in research. More detailed information about the study can be found by following the links provided.  If you have any questions about the research study, please speak to your medical team and contact the researchers directly.  APF does not endorse or recommend any specific study.  All responsibility for the study remains with the sponsors and investigators.

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