ILDnose study: a study investigating eNose technology as a diagnostic tool for pulmonary fibrosis

Upcoming study
Expected to open November 2020
This study is currently recruiting
Expected to close
This study is closed
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We will update this page with study results when available.
Information on study results are included below
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What next?

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What next?

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About this study

The diagnosis of pulmonary fibrosis can often be difficult and lengthy, due to the expertise required. This can leave people with an incorrect diagnosis or waiting a long time to know what is wrong.

The ILDnose study will assess people diagnosed with pulmonary fibrosis to see if the eNose technology is accurate and works well. The technology involves looking at the compounds in the air breathed out as potential biomarkers for diagnosis and disease progression

The aim of the study is to see if the new technology can be used to help with diagnosis and determine which type of pulmonary fibrosis someone has.


What is involved?

You may be able to take part in the study either before or after a routine outpatient hospital appointment. You will be asked to drink some water. For the exhaled breath analysis, you will need to breathe in and out into a machine via a disposable mouthpiece, whilst wearing a nose clip. This will then be repeated 1 minute after. The eNose technology will assess your breaths. The process is non-invasive and takes approximately 5-10 minutes in total. The breath is exerting but not as much as a spirometry blow that is done during lung function testing. You will be asked to blow softly and slowly for as long as you can after holding your breath for 5 seconds.  

If you are coming back for another clinic or lung function appointment, you may be asked to repeat the exhaled breath analysis.

Following the measurements with the new technology, you will be asked to complete a short survey and questionnaire. Information will also be collected from your medical records at the time of the assessment, 6 months, 12 months and then up to 24 months after.

Summary of involvement

Assessment at the same time as outpatient clinic appointment

Non-invasive use of eNose technology

Short survey and a questionnaire

Can I take part?

You may be able to take part if you are of any age and have a diagnosis of fibrotic ILD. Adults over the age of 18 years are are able to take part.

In research studies, there are lots of different reasons why you may or may not be able to take part. These are known as inclusion and exclusion criteria (see list below). Only the clinical trial team will be able to fully determine whether you are able to take part in the study. You can withdraw at any point.

If you are not able to take part in this research study, there may be other opportunities for you to take part in different studies.

To find our more about other research opportunities visit our research finder main page.

You may be able to join this study if all of these apply:

Aged 18 years and over

Diagnosis of fibrotic ILD

Fibrosis must have been seen on a HRCT scan less than 1 year before the study

You will not be able to join the study of any of the following applies:

Alcohol consumption less than 12 hours before the measurement

Physically not able to carry out the assessment

What difference could taking part make?

Taking part in ILDnose will help researchers to understand if eNose technology can be used to help with the diagnosis of pulmonary fibrosis. It has the potential to make the diagnosis pathway much easier and less burdensome.

Where does the study take place?

Study locations

Royal Brompton Hospital

How to take part

To take part, please discuss the study with your medical team at the Royal Brompton Hospital.

If you are not currently receiving care at a different hospital but able willing and able to travel, you can speak to your current healthcare team about being referred to the ILD Team at the Royal Brompton Hospital. This will enable you to be assigned to a consultant and take part in research studies.

Further information

The summary on this page provides information about an opportunity to participate in research. More detailed information about the study can be found via the following the links and through contacting the research team.

If you have any questions about this research study, please speak to your medical team.

This study is supported by

Erasmus Medical Center
Study ID number:

APF does not endorse or recommend any specific study. All responsibility for the study remains with the sponsors and investigators.

Every effort is made to keep these details up to date. If you are aware of any inaccuracies, please email